Within the unique world of Chinese Shar-Pei dogs, where distinctive wrinkles and skin issues are commonplace, there lies a hidden adversary that every Shar-Pei guardian should be well-versed in: Recurrent Fever Syndrome.
A Feverish Intrigue
As the name suggests, this syndrome revolves around inexplicable fevers that surge unexpectedly, wane over time, and may or may not respond to anti-inflammatory treatments. During these fever episodes, affected dogs display signs of malaise, lack of appetite, and general lethargy. Temperatures can skyrocket up to a scorching 107ºF, accompanied by swelling in the ankles (hocks) and even the muzzle. While it's customary for Shar-Pei to sport folds of skin around their ankles (called socks), the swelling witnessed during these episodes is unique and short-lived. Additional symptoms can include nausea, diarrhea, and discomfort.
Taming the Fever: A Crucial Skill
It's crucial to understand how to measure your dog's temperature, particularly as a fever of 106ºF is deemed a medical emergency. Normal canine body temperature ranges from 100-102ºF. Rapid identification and response are essential.
The Core Threat: Kidney Complications
However, what makes this syndrome a dire concern is the accompanying kidney damage. The presence of an abnormal protein named amyloid in the kidneys disrupts their ability to effectively filter protein. Consequently, vital blood proteins are lost in urine, alongside waste products. This protein loss leads to weight loss, a propensity for abnormal blood clot formation, and elevated blood pressure.
Deciphering the Mechanism
To understand the syndrome, it's essential to delve into the mechanics of Shar-Pei skin wrinkles. A surplus of a protein known as hyaluronan leads to the breed's distinctive skin folds. However, a mutation in this process results in excessive and poor-quality hyaluronan, triggering inflammation, fever, and organ damage. This mutation is often referred to as the "meat mouth" mutation.
Unveiling the Syndrome: Diagnosis and Screening
Diagnosing this syndrome necessitates clinical findings, including recurrent fevers and certain genetic variants. The degree of mutated copies of genes related to the "meat mouth" mutation dictates the severity of inflammation. For definitive diagnosis, genetic tests are available, and a fever episode occurring before 18 months of age is indicative. Regular urinalysis screenings to detect urinary protein loss are essential, as a red flag for the syndrome.
The Road to Recovery: Treatment and Support
During fever episodes, anti-inflammatory medications help manage high temperatures, along with pain relief. Yet, the true challenge lies in preventing kidney damage. Colchicine, a medication known for its interference with the formation of abnormal proteins, particularly amyloidosis, plays a pivotal role in averting kidney damage. However, the market unavailability of generic colchicine prompts pet owners to seek solutions through prescribed avenues or compounding pharmacies.
Nurturing with Antioxidants
Antioxidants play a vital role in preserving cell membranes and countering abnormal protein deposition. Recommendations encompass omega-3 fatty acid supplements, vitamin C, lecithin granules, and glucosamine supplements. A tailored protocol in consultation with a veterinarian aids in formulating an early intervention strategy.
The Herbal Angle
Herbal antioxidants and magnesium supplementation also contribute to balancing hyaluronan metabolism. Consulting with a veterinarian is imperative to outline a comprehensive plan.
In the enigmatic world of Shar-Pei dogs, where unique genetics give rise to distinctive traits, recurrent fever syndrome uncloaks itself as an intricate concern, requiring vigilance, early detection, and tailored interventions. By delving into the depths of this hidden struggle, guardians ensure their cherished companions thrive in health and happiness.
Don't have a vet in your area yet? We can help you find a local veterinarian.
If you have more questions, the GeniusVets Telehealth platform will give you unlimited access to text and/or video calls with board-certified veterinarians! To learn more click here.